Precipitation is a key variable in the hydrological cycle and essential input data in rainfall-runoff modeling. Rain gauge data are considered as one of the best data sources of precipitation but before further use, the data must be spatially interpolated. The process of interpolation is particularly challenging over mountainous areas due to complex orography and a usually sparse network of rain gauges. This paper investigates two deterministic interpolation methods (inverse distance weighting (IDW), and first-degree polynomial) and their impact on the outputs of semi-distributed rainfall-runoff modeling in a mountainous catchment. The performed analysis considers the aspect of interpolation grid size, which is often neglected in other than fully-distributed modeling. The impact of the inverse distance power (IDP) value in the IDW interpolation was also analyzed. It has been found that the best simulation results were obtained using a grid size smaller or equal to 750 m and the first-degree polynomial as an interpolation method. The results indicate that the IDP value in the IDW method has more impact on the simulation results than the grid size. Evaluation of the results was done using the Kling-Gupta efficiency (KGE), which is considered to be an alternative to the Nash-Sutcliffe efficiency (NSE). It was found that KGE generally tends to provide higher and less varied values than NSE which makes it less useful for the evaluation of the results.